Improving Progenitor Cell Selection to Promote Therapeutic Angiogenesis in Patients With Critical Limb Ischemia
نویسندگان
چکیده
منابع مشابه
Improving the level of amputation of the lower extremity after therapeutic endovascular intervention for patients with critical limb ischemia
Methods: We conducted a comparative study of two groups of patients suffering from arterial insufficiency of the lower extremities, and the decision taken to amputate above the knee for both of them. A group of patients selected for a therapeutic peripheral intervention, and the effect of this intervention in improving the level of amputation studied and calculated statistically. The study cond...
متن کاملHope for Therapeutic Angiogenesis for Patients with Critical Limb Ischemia: from Bench to Bedside
Peripheral arterial disease is a common but under-recognized problem. As the disease progresses, the patient might suffer from rest pain and/or ischemic ulceration critical limb ischemia (CLI). The primary goals for treating the limb symptoms of CLI are to improve functional capacity, exercise performance and qualify of life. Although numerous therapy options can be used for CLI, unfortunately,...
متن کاملCell Therapy in Patients with Critical Limb Ischemia
Critical limb ischemia (CLI) represents the most advanced stage of peripheral arterial obstructive disease (PAOD) with a severe obstruction of the arteries which markedly reduces blood flow to the extremities and has progressed to the point of severe rest pain and/or even tissue loss. Recent therapeutic strategies have focused on restoring this balance in favor of tissue survival using exogenou...
متن کاملBone Marrow Alterations and Lower Endothelial Progenitor Cell Numbers in Critical Limb Ischemia Patients
BACKGROUND Critical limb ischemia (CLI) is characterized by lower extremity artery obstruction and a largely unexplained impaired ischemic neovascularization response. Bone marrow (BM) derived endothelial progenitor cells (EPC) contribute to neovascularization. We hypothesize that reduced levels and function of circulating progenitor cells and alterations in the BM contribute to impaired neovas...
متن کاملTherapeutic Angiogenesis by Gene Therapy for Critical Limb Ischemia: Choice of Biological Agent
Peripheral artery disease (PAD) is caused by atherosclerosis, hardening and narrowing arteries over time due to buildup of fatty deposit in vascular bed called plaque. Severe blockage of an artery of the lower extremity markedly reduce blood flow, resulting in critical limb ischemia (CLI) manifested by a variety of clinical syndromes including rest pain in the feet or toes, ulcer and gangrene w...
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ژورنال
عنوان ژورنال: Circulation Journal
سال: 2018
ISSN: 1346-9843,1347-4820
DOI: 10.1253/circj.cj-18-0450